Funded Projects

Browse wide-ranging research at the frontiers of neuroscience supported by Wu Tsai Neurosciences Institute grants, awards, and training fellowships.

Wu Tsai Neurosciences Institute
Seed Grant
2017
The impact of early medial temporal lobe Tau in human cognitive aging
By measuring the aggregation of Tau protein in healthy older adults as well as those with Alzheimer's disease dementia using positron emission tomography imaging combined with high-resolution magnetic resonance imaging, this team hopes to predict who is at most risk for dementia in the future.
Wu Tsai Neurosciences Institute
Neuroscience:Translate Award
2019
Multi-modal deep learning for automated seizure localization

Developing an automated seizure detection and localization system based on deep neural networks, EEG data, and real-time video with the goal to dramatically increase neurologist diagnostic capabilities while improving quality of care.

Wu Tsai Neurosciences Institute
Seed Grant
2019
Sensory processing in a pre-seizure state
This team will leverage the power of silicon probes to record from hundreds of neurons in mouse epilepsy models to understand neural correlates of the pre-seizure EEG. These results will be used to optimize a real-time seizure prediction algorithm that will be tested in human patients.
Wu Tsai Neurosciences Institute
Seed Grant
2019
Genetic tools to determine circuit-specific roles of myelination

These tools will enable us to dissect how myelin contributes to specific brain circuits and types of neurons, bringing us closer to a holistic understanding of how cells in the brain collaborate to build a functional nervous system.

Wu Tsai Neurosciences Institute
Seed Grant
2019
Quantifying auditory-vocal affect in human social communication

This proposal brings together faculty with this diverse expertise to develop the first gold standard test of auditory-vocal affect. Once developed, validated, and normed, we will deploy this test in the clinical context of autism to quantify impairments and direct neurobiological investigation.

Wu Tsai Neurosciences Institute
Neuroscience:Translate Award
2020
Targeting DNA repair for neuroinflammation in stroke
Acute brain inflammation after stroke and head trauma causes adverse health outcomes affecting millions of patients each year in the U.S., and current treatments are insufficient. This project will test a promising new therapy to reduce inflammation by targeting the enzyme OGG1, a potentially important controller of acute inflammatory responses. This project is jointly supported by the Wu Tsai Neurosciences Institute and SPARK.
Wu Tsai Neurosciences Institute
Neuroscience:Translate Award
2020
The wearable ENG: A dizzy attack event monitor
Recurrent dizziness attacks are a debilitating condition for 10% of the population during their lifetime, and can lead to a complete inability to function, and to multiple hospital admissions and investigations chasing many potential diagnoses. This project aims to address the unmet need for means of tracking patients' specific symptoms, so that correct treatments can be identified that will improve patients' function and quality of life.
Wu Tsai Neurosciences Institute
Neuroscience:Translate Award
2020
PTS glove passive tactile stimulation for stroke rehab - Renewal

This team is developing wearable stimulation devices to improve limb function after stroke. The technology includes a tactile stimulation method, and the wireless, lightweight, and low-cost wearable computing devices to apply this stimulation.

Wu Tsai Neurosciences Institute
Neuroscience:Translate Award
2020
CPStim: Optimized non-invasive brain stimulation for chronic pain
In light of the dual public health crises of chronic pain and opioids, there is an urgent need to develop non-addictive alternative therapies for chronic pain. This project's goal is to develop a new protocol for transcranial magnetic stimulation — a non-invasive method of neuromodulation — that is optimized for chronic pain treatment.
Wu Tsai Neurosciences Institute
Neuroscience:Translate Award
2020
Deep learning for automated seizure localization
Current automated seizure detection software is slow, inaccurate and rarely precise enough for clinicians to rely upon. This project aims to use cutting-edge AI methods to develop a powerful new algorithm that will enable better seizure diagnosis and treatment plan formation.
Wu Tsai Neurosciences Institute
Neuroscience:Translate Award
2021
The wearable ENG: a dizzy attack event monitor, Dizzy DX - Renewal
Recurrent dizziness attacks are a debilitating condition for 10% of the population during their lifetime, and can lead to a complete inability to function, and to multiple hospital admissions and investigations chasing many potential diagnoses. This project aims to address the unmet need for means of tracking patients' specific symptoms, so that correct treatments can be identified that will improve patients' function and quality of life.
Wu Tsai Neurosciences Institute
Neuroscience:Translate Award
2021
Optimization of the African killifish platform for rapid drug screening for aggregate based neurodegenerative diseases
There are currently no available drugs for neurodegenerative diseases, including Alzheimer’s disease. Using the power of a new vertebrate aging model, the African killifish, this team is investigating age-dependent protein aggregation at a systems level and identifying aggregating proteins in the aging brain. There is huge potential to optimize the killifish platform for phenotypic screening of drug libraries, notably those targeted at protein aggregation, which is central to neurodegenerative diseases.
Wu Tsai Neurosciences Institute
Neuroscience:Translate Award
2021
Rapid and automated educational assessment through the web browser
This proposal seeks to translate new technology developed in the Brain Development & Education Lab into an automated reading ability assessment tool that would be widely distributed to schools, clinics and research labs through a sustainable non-profit model.
Wu Tsai Neurosciences Institute
Neuroscience:Translate Award
2021
Remote reliable measurements of movement using a Bluetooth enabled engineered keyboard solve an unmet need in neurological diseases

This team is developing a device that will enable accurate diagnosis of Parkinson’s disease via telemedicine. They initially introduced the technology of Quantitative DigitoGraphy (QDG) using a repetitive alternating finger tapping (RAFT) task on a musical instrument digital interface (MIDI) keyboard and will use Neuroscience: Translate funding for the next stage of device development.

Wu Tsai Neurosciences Institute
Neuroscience:Translate Award
2021
Extracochlear neurostimulation - Auricle

Sensorineural hearing loss is an increasingly prevalent condition that causes disability to over a third of US adults aged over 65. We are developing a breakthrough device to restore high-frequency hearing that preserves residual hearing through a reversible and minimally invasive approach.

Wu Tsai Neurosciences Institute
Neuroscience:Translate Award
2021
A minimally-invasive intracranial pressure microsensor (mICP) for long-term, continuous ambulatory monitoring
The limited available treatments (e.g., radiation, chemotherapy) for glioblastoma (GBM) can lead to swelling in the brain that causes elevated intracranial pressure (ICP), the timing of which is unpredictable; this results in the patient presenting to the emergency room with headaches, vomiting, or seizures, which leads to worsened quality of life and survival outcomes. We propose the refinement and pre-clinical validation of a pressure-sensing microfluidic ICP microsensor (mICP) that could be implanted in patients with GBM to detect elevated ICP early on.