Browse wide-ranging research at the frontiers of neuroscience supported by Wu Tsai Neurosciences Institute grants, awards, and training fellowships.
Projects
Vitruvius interface: Augmenting designer with real-time neurocognitive feedback
In this highly interdisciplinary project, PhD candidate Alberto Tono is pursuing the novel application of combined EEG and immersive reality to streamline workflows in building design and construction.
The contribution of temporal dynamics of visual processing to developmental dyslexia: a steady-state visual evoked potential (SSVEP) study
Fang Wang has been developing novel steady-state EEG techniques to reveal the underlying neural dynamics involved in the acquisition of reading skills in children. She will use the Koret award to extend her findings in typically developing children to children with dyslexia, illustrating how cortical challenges in the temporal dynamics of visual processing can contribute to dyslexia.
Pilot study of high-density EEG to assess markers of successful cognitive training in MCI
This team is working on understanding which patients with mild cognitive impairment (MCI) will best benefit from cognitive training. They are researching a multimodal approach to understand this question and will use their Koret pilot grant award to evaluate high-density EEG biomarkers for successful cognitive training in MCI.
EEG markers of self-efficacy and self-regulation in chronic pain patients with and without heavy drinking
This project aims to identify brain-based EEG markers of self-efficacy and self-regulation, which are the two critical treatment targets for people with chronic pain and comorbid heavy alcohol use. Such objective markers will assist in accurate diagnosis and assessment of treatment responses, which may enable a precision medicine approach for chronic pain and substance use disorders.
Assessing whether inhibitory rTMS improves brain pathology and language function in Self-limited Epilepsy with Centro-temporal Spikes (SeLECTS)
This team will use their Koret pilot grant award to study if language difficulties in children with epilepsy are caused by excessive connectivity in the brain. The team previously found that elevated connectivity is associated with poorer language, and that inhibitory transcranial magnetic stimulation (TMS) can reduce connectivity.
Mixed-reality neuronavigation for TMS treatment of depression
This team is developing a cutting-edge mixed reality application to improve the targeted delivery of transcranial magnetic stimulation (TMS). TMS is increasingly being used as a treatment for psychiatric conditions, but the success of the treatment depends critically on its precise delivery.
Sensory-entrained transcranial magnetic brain stimulation (seTMS) for enhanced motor and prefrontal plasticity
This team is developing new transcranial magnetic stimulation methods that optimize neuromodulation effects using music-induced brain state dynamics.
In vivo selection for gene mutations that counteract photoreceptor degeneration
Massively parallel microwire arrays for deep brain stimulation
A principled investigation into the heterogeneous coding properties of medial entorhinal cortex that support accurate spatial navigation
Navigation through an environment to a remembered location is a critical skill we use every day. How does our brain accomplish such a task? Over the last few decades, several lines of evidence have suggested that a brain region called medial entorhinal cortex (MEC) supports navigation by encoding information our location and movement within an environment.
Understanding why neurons die in disease
Many neurological diseases feature the death of neurons, but the mechanisms that mediate cell death in these disorders are unknown. Astrogliosis, the response of a cell-type called “astrocytes” to injury, is common to most diseases of the central nervous system (CNS), and recent studies in our lab suggest that some reactive astrocytes may release a protein that is potently toxic to neurons.
High-speed force probes for deconstructing the biophysics of mechanotransduction
The purpose of this collaborative project is to study neuronal mechanisms associated with social stress. In particular we will test whether the energy producing systems, known as mitochondria, in a specific set of brain cells are important to confer resilience to stressful stimuli. This research may lead to treatments of stress and anxiety disorders.
NeuroChoice Initiative (Phase 2)
Stanford NeuroTechnology Initiative (Phase 2)
Our goal is to develop the next generation of neural interfaces that match the resolution and performance of the biological circuitry. We will focus on two signature efforts to spearhead the necessary advances: high-density wire bundles for electrical recording and stimulation, and analog and digital bi-directional retinal prostheses for restoration of vision.
Stanford Brain Rejuvenation Project (Phase 2)
The Stanford Brain Rejuvenation Project is an initiative by leading aging researchers, neuroscientists, chemists, and engineers to understand the basis of brain aging and rejuvenation and how they relate to neurodegeneration.
Neuro-circuit interventional research consortium for understanding the brain and improving treatment
Combining a detailed understanding of brain circuits with technology that modulates neural activity to develop improved ways of treating mental health conditions.
NeuroVision Initiative
The goal is to forge an inter-disciplinary collaboration between physicists, biologists, chemists, and translational medical scientists by inventing new ways of visualizing the brain, from individual molecules to neuronal circuits to entire brain regions, from a normally functioning neuron to a diseased brain.
The NeuroFab: The hub for new ideas in neuro-engineering
Creating an incubator for next-generation neural interface platforms.
Brain-machine interfaces: Science, engineering, and application
Developing technology to interface with the brain and create intelligent prosthetics.
Stroke Collaborative Action Network
Breaches barriers in our understanding of stroke to develop therapies and improve stroke recovery.
Mechanisms of plasma proteins that rejuvenate the aged brain
One in three people will develop Alzheimer’s disease or another dementia during their lifetime, but effective treatment still does not exist despite intense efforts. Recently, blood from young mice has been found to rejuvenate several tissues of old mice, including the brain.
Systematic identification of wiring specificity molecules in Drosophila olfactory circuit using single cell RNA-seq
Precise neural circuit assembly is critical for appropriate function of the nervous system. A functional circuit requires proper targeting and matching of axons and dendrites of pre- and post-synaptic neurons. However, our understanding of the mechanisms that establish wiring specificity of complex neural circuit is far from complete.
Developing a dopamine and neural systems model of anhedonia
More than 60 million people in the United States currently suffer from a serious mental illness, and the associated financial, productivity and human suffering costs are only projected to rise in the near future.
In vivo analysis of cAMP dynamics in developing glial cells
Cyclic adenosine monophosphate (cAMP) is an important intracellular messenger that plays a critical role in the development of the central and peripheral nervous system. However, the mechanisms of action of cAMP in the nervous system development are poorly understood and there are currently no suitable methods to visualize cAMP in the cells of living animals.