Browse wide-ranging research at the frontiers of neuroscience supported by Wu Tsai Neurosciences Institute grants, awards, and training fellowships.
Projects
Neuronal and genetic imprints of male mating experience
We understand a lot about how the brain gets rewired when learning a new skill by repetitive practice, such as hitting a curveball. However, how learning and experience alter the innate behaviors that we are born with is poorly understood.
Restoring vision with epiretinal prostheses
Millions of people are blind, yet we still don’t have the technology to satisfactorily restore vision. I aim to create a prosthetic device to do so. This device can be implanted in the eyes of a blind patient, resting on a tissue layer called the retina.
Improving BCI generalizability with multi-task modeling and autocalibration
Brain-computer interfaces (BCIs) are systems that enable using neural activity to control and interact with external devices. For people who lose the ability to move or speak due to injury or disease, BCIs provide a potential avenue to restore this loss of function.
Tracking Parkinson’s Disease with transformer models of everyday looking behaviors
It is more common nowadays for people to have their own wearable devices to measure physiological signals like heart rate and respiration to keep track of physical diseases. However, monitoring decline in cognitive functions or development of neurodegenerative diseases, such as Parkinson’s (PD), is still complex and tricky.
Microglia-Mediated Astrocyte Activation in Chronic Pain
While acute pain is an important biological signal in response to injured tissue, chronic pain occurs when the pain signaling outlasts the initial injury and has deleterious effects on health and quality of life. Chronic pain represents an enormous public health burden with few therapeutic options.
High-Fidelity Artificial Retina for Vision Restoration
This team will use their Neuroscience:Translate award to develop a large-scale bi-directional neural interface that will restore high-fidelity vision to people blinded by retinal degeneration.
Programmable RNA editing in Parkinson’s disease therapy
This team will use their Neuroscience:Translate award to employ a novel therapeutic technique to correct pathogenic mutations causing Parkinson’s disease.
New Thrombectomy Device for Endovascular Neurosurgery
This team will use their Neuroscience:Translate award to develop an entirely new class of ischemic stroke treatment device that will lead to improved clot extraction to improve the success of endovascular thrombectomy.
Development of an Ultrasound Neuromodulation Therapy to Treat Rheumatoid Arthritis
This team will use their Neuroscience:Translate award to develop the first wearable ultrasound (US) device for the treatment of inflammatory diseases, such as Rheumatoid Arthritis (RA) and Inflammatory Bowel Disease.
Small molecule ion channel modulator to treat acute episodes of peripheral vertigo
This team is developing a small molecule that targets a voltage-gated ion channel within the inner ear for the symptomatic relief of peripheral vertigo attacks. They will use their Neuroscience:Translate award to further develop this molecule to restore normal function and improve activities of daily living for patients experiencing peripheral vertigo.
Multifunctional vascular-like electronics for integration and monitoring of human neural organoids
This study will introduce a vascular-like electronic system that merges seamlessly with neural organoids,
establishing an integrated vascular-electronic-neural network. This envisaged platform holds the promise of heralding a transformative phase in the evolution of human neural organoid research and elucidating the
fundamental understanding on the roles of oxygen and nutrient perfusion during neural development.
Neuronal innervation dynamics in uterine function and maternal age-associated miscarriage
This proposal addresses three interconnected, yet independent aims focused on the neural mechanisms implicated in age-associated miscarriages. First, the proposal aims to construct a comprehensive neuro-uterine atlas delineating neuronal subtypes innervating the uterus, elucidating how innervation patterns and transcriptome profiles evolve with age. Second, the proposal aims to implement cutting-edge tissue clearing techniques on extracted uteri to discern alterations in uterine innervation patterns and signaling across the rodent estrous cycle and the first trimester of pregnancy.
Creating a pharmacologic stroke recovery therapy
This team has identified a promising protein-based therapeutic to improve stroke recovery. The team will use the Neuroscience:Translate award to identify key components of this protein to maximize its therapeutic potential for stroke treatments.
Clinical translation of a new PET radiotracer for mapping innate immune activation in multiple sclerosis and other neurodegenerative diseases
This team recently identified a selective biomarker of inflammation-promoting immune cells in the central nervous system. They will use their Neuroscience:Translate award to develop non-invasive molecular imaging strategies to distinguish between harmful (pro-inflammatory) and helpful (anti-inflammatory) immune cells in patients with Multiple sclerosis (MS).
Assessing the feasibility of an autologous cell/gel therapy for spinal cord injury
This team has developed a new therapy for patients with spinal cord injury, involving injection into the spinal cord of patient-derived stem cells within an engineered protective gel. They will use their Neuroscience:Translate award to further test and develop this novel therapy in preparation for first-in-human clinical trials.
Targeting mitochondria in glioblastoma
This team recently discovered that a small molecule they had originally developed to treat Parkinson’s disease can also reduce the volume of glioblastoma tumors – the most common form of aggressive brain tumor — by targeting the mitochondrial protein Miro1. They will use their Neuroscience:Translate award to study the mechanisms of the compound’s anti-tumor action and prepare to apply for investigational-new-drug status to move this discovery toward the clinic.
How do early life experiences shape the neural underpinnings of caregiver olfactory recognition?
The ability of an infant to distinguish caregivers from strangers is fundamental for survival early in life. Across
many taxa, newborns use olfactory cues to recognize caregivers. Caregiver odors induce proximity-seeking
behavior and alleviate stress in neonatal mammals, including humans. Since all altricial animals rely on parental
care for survival and children with developmental disorders (e.g., fragile X syndrome and autism) often have
deficits in the olfactory system, it is essential to understand the mechanisms for linking caregiver odors with
affiliative behavior.
Interrogating the effects of serotonin and dopamine on neural activity in the nucleus accumbens during aggression
Studying the brain circuits involved in aggression will help us tackle big social issues like hate crimes, antisocial
behavior, and violence. Imagine if we could better understand why some people act aggressively towards
others—we could use this knowledge to protect people from harm and create a world where everyone feels safe. Chemicals in our brain, such as dopamine and serotonin, affect neural activity to modulate behavior. When we experience something rewarding, like having good food or meeting friends, dopamine is released in the brain.
Interpretable machine learning to decipher gene regulation in brain development and disruption in disease
Brain development is a complex process where cells must self-renew and differentiate at the right place and right time. Gene regulation during development involves sequences in the genome which affect the expression of genes locally, and transcription factors, proteins that bind these sequences and activate genes throughout the genome. At active regulatory sequences and genes, DNA is accessible to these proteins, while inactive DNA is tightly compacted.
Mechanisms of plasma proteins that rejuvenate the aged brain
One in three people will develop Alzheimer’s disease or another dementia during their lifetime, but effective treatment still does not exist despite intense efforts. Recently, blood from young mice has been found to rejuvenate several tissues of old mice, including the brain.
Systematic identification of wiring specificity molecules in Drosophila olfactory circuit using single cell RNA-seq
Precise neural circuit assembly is critical for appropriate function of the nervous system. A functional circuit requires proper targeting and matching of axons and dendrites of pre- and post-synaptic neurons. However, our understanding of the mechanisms that establish wiring specificity of complex neural circuit is far from complete.
Developing a dopamine and neural systems model of anhedonia
More than 60 million people in the United States currently suffer from a serious mental illness, and the associated financial, productivity and human suffering costs are only projected to rise in the near future.
In vivo analysis of cAMP dynamics in developing glial cells
Cyclic adenosine monophosphate (cAMP) is an important intracellular messenger that plays a critical role in the development of the central and peripheral nervous system. However, the mechanisms of action of cAMP in the nervous system development are poorly understood and there are currently no suitable methods to visualize cAMP in the cells of living animals.
Combining electrical and optical measurements on voltage-gated sodium channel toxins
Ion channels in the membranes of neuronal cells are the key regulators of neuronal signaling. An ion channel works as a gate that can open and close to allow specific molecules to enter or leave the cell. One important type of ion channels are voltage-gated sodium channels (NaVs), which are essential for many processes in our brain.